Paediatrics
Paediatrics

Thiopurine therapy enhances immune checkpoint inhibitor efficacy in low-mutational burden melanoma: A promising anticancer approach

Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e2423246122. doi: 10.1073/pnas.2423246122. Epub 2025 Feb 24. ABSTRACT A key limitation of immune checkpoint inhibitors (ICI) …

The risk of refracture and malunion in children treated for diaphyseal forearm fractures: a retrospective cohort study

Acta Orthop. 2025 Feb 24;96:189-194. doi: 10.2340/17453674.2025.42851. ABSTRACT BACKGROUND AND PURPOSE: The optimal treatment modality for pediatric diaphyseal forearm fractures is debated. While nonoperative treatment …

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

Elife. 2025 Feb 24;13:RP97830. doi: 10.7554/eLife.97830. ABSTRACT Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage, and altered metabolism following …

Whole-Body Hypothermia for Neonatal Encephalopathy in Preterm Infants 33 to 35 Weeks’ Gestation: A Randomized Clinical Trial

JAMA Pediatr. 2025 Feb 24. doi: 10.1001/jamapediatrics.2024.6613. Online ahead of print. ABSTRACT IMPORTANCE: Hypothermia begun less than 6 hours after birth reduces death or disability …