Paediatrics
Paediatrics

Image-guided targeting of mitochondrial metabolism sensitizes pediatric malignant rhabdoid tumors to low-dose radiotherapy

Sci Adv. 2025 May 23;11(21):eadv2930. doi: 10.1126/sciadv.adv2930. Epub 2025 May 23. ABSTRACT Tumor hypoxia leads to radioresistance and markedly worse clinical outcomes for pediatric malignant …

Immune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity

Sci Adv. 2025 May 23;11(21):eadr6940. doi: 10.1126/sciadv.adr6940. Epub 2025 May 23. ABSTRACT Aggressive brain tumors often exhibit immunologically ‘cold’ microenvironment, where the vascular barrier impedes …

PeRiOperative Glucose PRAgMatic (PROGRAM): a randomized trial of standardized insulin management in surgical patients

Anesthesiology. 2025 May 23. doi: 10.1097/ALN.0000000000005577. Online ahead of print. ABSTRACT BACKGROUND: Perioperative hyperglycemia is associated with adverse patient outcomes including surgical site infections. This …

Developing a Core Outcome Set for Pediatric and Adult Acute and Chronic Pain Extended Reality Trials: Delphi Consensus-Building Process

J Med Internet Res. 2025 May 23;27:e58947. doi: 10.2196/58947. ABSTRACT BACKGROUND: Appropriate outcome assessment strategies and high-quality trials are critical to advancing care of patients …

Exploring the rationale for prescribing ankle-foot orthoses and supramalleolar orthoses to children with cerebral palsy among pediatric orthotists in Australia

Prosthet Orthot Int. 2025 May 22. doi: 10.1097/PXR.0000000000000457. Online ahead of print. ABSTRACT OBJECTIVES: To explore the rationale for prescribing ankle-foot orthoses and supramalleolar orthoses …

Correction: Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis

Pharmacoeconomics. 2025 May 23. doi: 10.1007/s40273-025-01502-2. Online ahead of print. NO ABSTRACT PMID:40408034 | DOI:10.1007/s40273-025-01502-2