Clin Nucl Med. 2025 Nov 18. doi: 10.1097/RLU.0000000000006209. Online ahead of print.
ABSTRACT
Fibroblast activation protein (FAP) is a membrane-bound protease predominantly expressed on the surface of cancer-associated fibroblasts activated within the solid tumor microenvironment, while its expression remains minimal in normal tissues. Following radiolabeling, FAP-2286 has demonstrated favorable diagnostic performance and promising therapeutic potential in cancer. The image illustrates the accumulation of 177Lu-FAP-2286 in the gallbladder, but correlative imaging and knowledge of the radiopharmaceutical helped to avoid a diagnostic pitfall.
PMID:41359364 | DOI:10.1097/RLU.0000000000006209
