Clin Nucl Med. 2026 Mar 31. doi: 10.1097/RLU.0000000000006377. Online ahead of print.
ABSTRACT
A 10-year-old child presented with episodic headache, diaphoresis, and dizziness during micturition straining, raising clinical suspicion for paraganglioma. 123I-MIBG SPECT/CT revealed no abnormal radiotracer uptake in the bladder mass or enlarged lesions. In contrast, 18F-FDG PET/CT demonstrated increased metabolic activity with marked 18F-FDG uptake in these same regions. Histopathological examination following surgical resection confirmed the diagnosis of malignant paraganglioma with multiple metastases. This case illustrates that bladder paragangliomas may exhibit positive 18F-FDG PET/CT findings despite negative 123I-MIBG SPECT/CT results, highlighting the complementary role of functional imaging modalities in the diagnostic evaluation of bladder paragangliomas.
PMID:41950229 | DOI:10.1097/RLU.0000000000006377
