J Physiol. 2025 Sep 14. doi: 10.1113/JP289160. Online ahead of print.
ABSTRACT
Calcium-activated Cl– channels (CaCC) are widely expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction. In this review we discuss recent advances on the roles of TMEM16A in gastrointestinal and vascular smooth muscle contractility, including its segment and cell type-specific effects. We also discuss recent physiological and pharmacological evidence suggesting potential therapeutic utility of TMEM16A modulators in gastrointestinal and cardiovascular diseases associated with altered smooth muscle contractility.
PMID:40946329 | DOI:10.1113/JP289160
