Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(12):69-74. doi: 10.17116/jnevro202412412169.
ABSTRACT
OBJECTIVE: Identification of therapeutic targets in the treatment of adolescent depression with attenuated symptoms of schizophrenia and assessment of the effectiveness of therapeutic interventions.
MATERIAL AND METHODS: One hundred and twenty-three patients (mean age 19.6±2.3 years) hospitalized in the clinic of the Mental Health Research Center for adolescent depression with non-psychotic mental disorders (ICD-10: F31, F32, F33, F34; F60; F21) were examined. Group 1 (44.7%, n=55) received only psychopharmacotherapy, Group 2 (24.4%, n=30) additionally received a course of repetitive transcranial magnetic stimulation (rTMS) therapy, Group 3 (13.0%, n=16) was administered to TMS, Group 4 (17.9%, n=22) received psychotherapy. Psychometric scales (HDRS SOPS CGI, SANS) were used. Statistical analysis was performed using Statistica 12 software.
RESULTS: The addition of additional non-drug treatment methods (brain feedback and TMS) did not lead to a reliable improvement in the results, and in some cases negative results were obtained. Psychotherapy conducted according to protocols, taking into account the clinical characteristics of patients, demonstrated a significantly higher treatment effectiveness (p<0.05).
CONCLUSION: Additional therapy targets for adolescent depression with attenuated symptoms of schizophrenia have been identified, including specific mild positive, negative symptoms, and disorganization symptoms, which, although not prominent, are fundamentally important in the effectiveness of treatment.
PMID:39731373 | DOI:10.17116/jnevro202412412169
