J Pediatr. 2025 Apr 10:114582. doi: 10.1016/j.jpeds.2025.114582. Online ahead of print.
ABSTRACT
Infants born preterm and infants born at term with neurological injury continue to be identified as “high-risk” for adverse neurodevelopmental outcomes. To mitigate neurodevelopmental risk, these infants may receive a wide range of habilitative and early intervention strategies ranging from minimal support to intensive therapies in the neonatal intensive care unit and early childhood. There is a growing body of science regarding the opportunity for targeted individualized strategies, related to the nature and timing of injury, to improve neurodevelopmental outcomes in high-risk infant populations. This report aims to briefly review the current state of understanding of neurobiological injury in high-risk infant populations, discuss strategies for early detection along with critical periods for intervention, and offer suggestions for development of tailored neurodevelopmental or neurohabilitative care approaches to optimize outcomes in hospitalized infants.
PMID:40221018 | DOI:10.1016/j.jpeds.2025.114582
