Int J Obes (Lond). 2025 Sep 25. doi: 10.1038/s41366-025-01911-5. Online ahead of print.
ABSTRACT
Intentional weight loss is often followed by unintentional weight regain. The causes of weight regain are uncertain but may include a myriad of responses that result in increased hunger and decreased energy expenditure. An individual’s psychological state and social and physical environments are also thought to influence weight regain in ways that can either support or derail weight loss maintenance. Funded by the National Institutes of Health, the Physiology of the WEight Reduced State (POWERS) study is a multi-center clinical trial aimed at describing the molecular, cellular, physiological, behavioral, environmental and psychosocial factors that may be associated with an individual’s ability to maintain their new weight after weight loss. This report provides the rationale for and describes the environmental, psychological and social determinants of health measures used in the POWERS study.
PMID:40999198 | DOI:10.1038/s41366-025-01911-5
