Nat Hum Behav. 2025 Oct 16. doi: 10.1038/s41562-025-02319-x. Online ahead of print.
ABSTRACT
Research on mental health has traditionally separated the study of ill-being, including clinically defined mental and behavioural disorders and subthreshold problems, from the study of well-being, which encompasses factors such as life satisfaction and positive affect. Although previous reviews of studies primarily using self-report scales indicate that ill-being and well-being are distinct yet interconnected constructs, a deeper examination of their relationship is lacking. In this Perspective, we synthesize genetic, biological, developmental, psychosocial, societal, cultural and clinical research on ill-being and well-being. Our review reveals substantial genetic overlap and similar biological underpinnings for ill-being and well-being. By contrast, environmental factors and societal changes often exert divergent influences. We propose a differentiated multidisciplinary framework in which the shared and unique determinants, predictors, mechanisms and consequences of mental ill-being and well-being vary across levels of analysis, offering a more nuanced understanding of the interconnections.
PMID:41102498 | DOI:10.1038/s41562-025-02319-x
