paediatrics
paediatrics

paediatrics

Paediatrics

Effect of prebiotic oligosaccharides on bowel habit and the gut microbiota in children with functional constipation (Inside study): study protocol for a randomised, placebo-controlled, multi-centre trial

Trials. 2024 Apr 5;25(1):238. doi: 10.1186/s13063-024-08050-8. ABSTRACT BACKGROUND: Functional constipation (FC) in children is a common gastrointestinal disorder with a worldwide-pooled prevalence of 9.5%. Complaints …

Paediatrics

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

Mol Neurodegener. 2024 Apr 5;19(1):31. doi: 10.1186/s13024-024-00723-x. ABSTRACT BACKGROUND: Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health …

Paediatrics

Does the use of higher versus lower oxygen concentration improve neurodevelopmental outcomes at 18-24 months in very low birthweight infants?

Trials. 2024 Apr 4;25(1):237. doi: 10.1186/s13063-024-08080-2. ABSTRACT BACKGROUND: Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85-95% within …

Paediatrics

EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics

Acta Neuropathol Commun. 2024 Apr 4;12(1):51. doi: 10.1186/s40478-024-01759-2. ABSTRACT DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour …

Paediatrics

WHO’s end of TB targets: unachievable by 2035 without addressing under nutrition, forced displacement, and homelessness: trend analysis from 2015 to 2022

BMC Public Health. 2024 Apr 4;24(1):961. doi: 10.1186/s12889-024-18400-5. ABSTRACT Tuberculosis (TB) remains a significant global health challenge, despite the World Health Organization (WHO) actively working …

Paediatrics

GBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease

Orphanet J Rare Dis. 2024 Apr 4;19(1):144. doi: 10.1186/s13023-024-03132-x. ABSTRACT BACKGROUND: Osteoporosis and its primary complication, fragility fractures, contribute to substantial global morbidity and mortality. …

Paediatrics

Adaptation and qualitative evaluation of the BETTER intervention for chronic disease prevention and screening by public health nurses in low income neighbourhoods: views of community residents

BMC Health Serv Res. 2024 Apr 4;24(1):427. doi: 10.1186/s12913-024-10853-z. ABSTRACT BACKGROUND: The BETTER intervention is an effective comprehensive evidence-based program for chronic disease prevention and …

Paediatrics

Increasing access to mental health supports for 12-17-year-old Indigenous youth with the JoyPop mobile mental health app: study protocol for a randomized controlled trial

Trials. 2024 Apr 4;25(1):234. doi: 10.1186/s13063-024-08076-y. ABSTRACT BACKGROUND: Indigenous youth in Northwestern Ontario who need mental health supports experience longer waits than non-Indigenous youth within …

Paediatrics

Effect of play-based intervention on children’s mental status and caregiver involvement during hospitalization: findings from Pakistan

BMC Pediatr. 2024 Apr 4;24(1):239. doi: 10.1186/s12887-024-04659-5. ABSTRACT BACKGROUND: The nurturing care framework (NCF) encompasses responsive caregiving, health, nutrition, safety and security by parents and …

Paediatrics

Effectiveness and cost-effectiveness of community-based mental health services for individuals with severe mental illness in Iran: a systematic review and meta-analysis

BMC Psychiatry. 2024 Apr 4;24(1):256. doi: 10.1186/s12888-024-05666-7. ABSTRACT BACKGROUND: Severe mental illness (SMI) imposes a substantial worldwide burden of disability, highlighting the need for comprehensive …