paediatrics
paediatrics

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s disease

Alzheimers Dement. 2026 Apr;22(4):e71306. doi: 10.1002/alz.71306. ABSTRACT INTRODUCTION: While the apolipoprotein E (APOE) ε4 allele is a major risk factor for Alzheimer’s disease (AD), the …

Differential expression of cancer-related genes supports prediction of poor response to first-line treatments in T-ALL pediatric patients with high minimal residual disease

Mol Oncol. 2026 Apr 9. doi: 10.1002/1878-0261.70234. Online ahead of print. ABSTRACT T-cell acute lymphoblastic leukemia (T-ALL) originates from the malignant transformation of immature lymphoblasts …

Sex-Specific Prognostic Value of Aortic Valve Calcium and the Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis (MESA)

Circ Cardiovasc Imaging. 2026 Apr 9:e018849. doi: 10.1161/CIRCIMAGING.125.018849. Online ahead of print. ABSTRACT BACKGROUND: In general, females have lower aortic valve calcium (AVC) scores compared …

Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network

Circulation. 2026 Apr 9. doi: 10.1161/CIRCULATIONAHA.125.076218. Online ahead of print. ABSTRACT BACKGROUND: Preeclampsia affects approximately 1 in 10 pregnancies, leading to severe complications and long-term …