paediatrics
paediatrics

Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial

Stem Cell Res Ther. 2025 May 30;16(1):268. doi: 10.1186/s13287-025-04404-4. ABSTRACT BACKGROUND: This study evaluated the effectiveness of intrathecal autologous bone marrow mononuclear cell (BMMNC) therapy …

Effects of vitamin D supplementation on symptoms and clinical outcomes in adults with different baseline vitamin D levels: an interventional study

J Health Popul Nutr. 2025 May 29;44(1):176. doi: 10.1186/s41043-025-00881-8. ABSTRACT BACKGROUND: Hypovitaminosis D or vitamin D deficiency is a significant public health issue. Several vitamin …

Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors

Mol Cancer. 2025 May 30;24(1):154. doi: 10.1186/s12943-025-02352-4. ABSTRACT Epigenetic modulators in combination with proapoptotic drugs have become the standard of care treatment in hematological malignancies. …

Canakinumab treatment patterns in sJIA, FMF, TRAPS, and MKD/HIDS: real-world insights from a Belgian non-interventional study

BMC Rheumatol. 2025 May 29;9(1):64. doi: 10.1186/s41927-025-00515-w. ABSTRACT BACKGROUND: Canakinumab, an IL-1β inhibitor, has demonstrated long-term efficacy and safety in patients with sJIA, FMF, TRAPS, …

A novel c.116 - 117 del variant in Unverricht-Lundborg disease: first ULD report in large Chinese population and review of the pathogenetic variants in CSTB gene

Acta Epileptol. 2025 May 29;7(1):32. doi: 10.1186/s42494-025-00216-4. ABSTRACT BACKGROUND: Unverricht-Lundborg disease (ULD) is a rare autosomal recessive neurodegenerative disorder, often caused by biallelic promoter expansions …