paediatrics
paediatrics

Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor-CD74 signaling

Sci Transl Med. 2025 Dec 3;17(827):eadr2277. doi: 10.1126/scitranslmed.adr2277. Epub 2025 Dec 3. ABSTRACT Aberrant proteostasis in alveolar type 2 epithelial cells (AEC2s) contributes to idiopathic …

Maternal lipidomic signatures of preterm and small-for-gestational-age newborn infants in low- and middle-income countries

Sci Adv. 2025 Dec 5;11(49):eadu9145. doi: 10.1126/sciadv.adu9145. Epub 2025 Dec 3. ABSTRACT Maternal lipid levels change dynamically during gestation to support normal fetal growth. To …

Safety of co-administration of injectable vaccines in individuals under 18 years of age: A systematic literature review

Hum Vaccin Immunother. 2025 Dec;21(1):2592425. doi: 10.1080/21645515.2025.2592425. Epub 2025 Dec 3. ABSTRACT Co-administration of multiple vaccines during a single clinical visit is common in pediatric …

Background Mucosal Inflammation Affects Colorectal Cancer Prognosis in Ulcerative Colitis: A Nationwide, Multicenter Study

J Crohns Colitis. 2025 Dec 3:jjaf207. doi: 10.1093/ecco-jcc/jjaf207. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Chronic background mucosal inflammation contributes to colorectal cancer (CRC) …

Semaglutide and Early-Stage Metabolic Abnormalities in Individuals With Schizophrenia Spectrum Disorders: A Randomized Clinical Trial

JAMA Psychiatry. 2025 Dec 3. doi: 10.1001/jamapsychiatry.2025.3639. Online ahead of print. ABSTRACT IMPORTANCE: Individuals with schizophrenia spectrum disorders treated with second-generation antipsychotics (SGAs) are at …

OTMODE: An Optimal Transport Theory-Based Framework for Identifying Differential Features in Single-Cell Multi-Omics Data

Bioinformatics. 2025 Dec 3:btaf650. doi: 10.1093/bioinformatics/btaf650. Online ahead of print. ABSTRACT MOTIVATION: Single-cell technologies enable high-resolution cellular studies but face challenges in identifying differential features …