paediatrics
paediatrics

Screening and interventional strategies for the late effects and toxicities of hematological malignancy treatments in pediatric survivors

Expert Rev Hematol. 2024 Jun 20. doi: 10.1080/17474086.2024.2370559. Online ahead of print. ABSTRACT INTRODUCTION: Advancements in pediatric cancer treatment have increased patient survival rates; however, …

Trophoblast cell surface antigen-2: a promising new biomarker and potential therapeutic target in penile squamous cell carcinoma

BJU Int. 2024 Jun 19. doi: 10.1111/bju.16442. Online ahead of print. ABSTRACT OBJECTIVE: To evaluate the potential utility of antibody-drug conjugates targeting trophoblast cell surface …

Development and Evaluation of Ontogeny Functions of the Major UDP-Glucuronosyltransferase Enzymes to Underwrite Physiologically Based Pharmacokinetic Modeling in Pediatric Populations

J Clin Pharmacol. 2024 Jun 19. doi: 10.1002/jcph.2484. Online ahead of print. ABSTRACT Uridine 5′-diphospho-glucuronosyltransferases (UGTs) demonstrate variable expression in the pediatric population. Thus, understanding …

Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability

Behav Brain Funct. 2024 Jun 19;20(1):14. doi: 10.1186/s12993-024-00240-3. ABSTRACT BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males …

Nutritional interventions in children with acute lymphoblastic leukemia undergoing antineoplastic treatment: a systematic review

BMC Nutr. 2024 Jun 19;10(1):89. doi: 10.1186/s40795-024-00892-4. ABSTRACT BACKGROUND: A compromised nutritional status jeopardizes a positive prognosis in acute lymphoblastic leukemia (ALL) patients. In low- …