paediatrics
paediatrics

Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study-a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

BMJ Open. 2024 Jun 19;14(6):e082453. doi: 10.1136/bmjopen-2023-082453. ABSTRACT PURPOSE: The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, …

Using mobile health to expedite access to specialty care for youth presenting to the emergency department with concussion at highest risk of developing persisting symptoms: a protocol paper for a non-randomised hybrid implementation-effectiveness trial

BMJ Open. 2024 Jun 19;14(6):e082644. doi: 10.1136/bmjopen-2023-082644. ABSTRACT INTRODUCTION: Paediatric concussion is a common injury. Approximately 30% of youth with concussion will experience persisting postconcussion …

Screening for adverse social conditions in child healthcare settings: protocol for a systematic review

BMJ Open. 2024 Jun 19;14(6):e081958. doi: 10.1136/bmjopen-2023-081958. ABSTRACT INTRODUCTION: Adverse social conditions affect children’s development and health outcomes from preconception throughout their life course. Early …

Application value of multi-gene mutation detection in the clinical management of pediatric papillary thyroid carcinoma: a preliminary exploration

Front Endocrinol (Lausanne). 2024 Jun 5;15:1405142. doi: 10.3389/fendo.2024.1405142. eCollection 2024. ABSTRACT OBJECTIVES: Thyroid cancer rarely occurs in children and adolescents. Molecular markers such as BRAF, …

Exploring early DNA methylation alterations in type 1 diabetes: implications of glycemic control

Front Endocrinol (Lausanne). 2024 Jun 5;15:1416433. doi: 10.3389/fendo.2024.1416433. eCollection 2024. ABSTRACT BACKGROUND: Prolonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant …

Exploring Splicing Modulation as an Innovative Approach to Combat Pancreatic Cancer: SF3B1 Emerges as a Prognostic Indicator and Therapeutic Target

Int J Biol Sci. 2024 Jun 3;20(8):3173-3184. doi: 10.7150/ijbs.92671. eCollection 2024. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges in terms of prognosis and treatment. …

Reproductive and fetal toxicity studies of histamine H3 receptor antagonist DL76 used in mice to prevent maximal electroshock-induced seizure

Front Pharmacol. 2024 Jun 5;15:1364353. doi: 10.3389/fphar.2024.1364353. eCollection 2024. ABSTRACT Introduction: Brain histamine is considered an endogenous anticonvulsant and histamine H1 receptor. H1R antagonists have, …