paediatrics
paediatrics

snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response

Acta Neuropathol Commun. 2024 Jun 21;12(1):102. doi: 10.1186/s40478-024-01821-z. ABSTRACT Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most …

Trends and off-label utilization of antipsychotics in children and adolescents from 2016 to 2021 in China: a real-world study

Child Adolesc Psychiatry Ment Health. 2024 Jun 21;18(1):77. doi: 10.1186/s13034-024-00766-4. ABSTRACT BACKGROUND: Global antipsychotic usage, including off-label prescriptions, has increased in recent decades. However, trends …

An evaluation of dexmedetomidine in combination with midazolam in pediatric sedation: a systematic review and meta-analysis

BMC Anesthesiol. 2024 Jun 21;24(1):210. doi: 10.1186/s12871-024-02570-1. ABSTRACT BACKGROUND: Dexmedetomidine and midazolam are commonly used sedatives in children. We conducted a systematic review and meta-analysis …

Co-designing discharge communication interventions for mental health visits to the pediatric emergency department: a mixed-methods study

Res Involv Engagem. 2024 Jun 21;10(1):64. doi: 10.1186/s40900-024-00594-y. ABSTRACT BACKGROUND: Discharge communication is essential to convey information regarding the care provided and follow-up plans after …

Attitudes toward and training in medications for opioid use disorders: a descriptive analysis among employees in the youth legal system and community mental health centers

Subst Abuse Treat Prev Policy. 2024 Jun 21;19(1):32. doi: 10.1186/s13011-024-00614-w. ABSTRACT BACKGROUND: Research demonstrates gaps in medications for opioid use disorder uptake (MOUDs; methadone, buprenorphine, …

Effect of vagus nerve stimulation on emergency department utilization in children with drug-resistant epilepsy: a retrospective cohort study

J Neurosurg Pediatr. 2024 Jun 21:1-8. doi: 10.3171/2024.4.PEDS23310. Online ahead of print. ABSTRACT OBJECTIVE: Epilepsy affects approximately 470,000 children in the United States. The estimated …