paediatrics
paediatrics

Redistribution of PU.1 partner transcription factor RUNX1 binding secures cell survival during leukemogenesis

EMBO J. 2024 Nov 14. doi: 10.1038/s44318-024-00295-y. Online ahead of print. ABSTRACT Transcription factors (TFs) orchestrating lineage-development often control genes required for cellular survival. However, …

Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies

Commun Biol. 2024 Nov 14;7(1):1512. doi: 10.1038/s42003-024-07236-9. ABSTRACT Meta-analysis of genome-wide association studies (GWAS) across diverse populations offers power gains to identify loci associated with …

The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder

Mol Psychiatry. 2024 Nov 14. doi: 10.1038/s41380-024-02825-w. Online ahead of print. ABSTRACT Eating disorders (EDs) commonly co-occur with other psychiatric and neurodevelopmental disorders including attention-deficit/hyperactivity …

Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics

Commun Biol. 2024 Nov 14;7(1):1506. doi: 10.1038/s42003-024-07015-6. ABSTRACT Population studies have shown that the infant’s microbiome and metabolome undergo significant changes in early childhood. However, …