paediatrics
paediatrics

Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections

J Antimicrob Chemother. 2024 Nov 21:dkae423. doi: 10.1093/jac/dkae423. Online ahead of print. ABSTRACT BACKGROUND: Cefalexin, a first-generation cephalosporin, is commonly used as oral continuation therapy …

Assessing differences among persistent, episodic, and non- high-need high-cost hospitalized children in China after categorization by an unsupervised learning algorithm

Arch Public Health. 2024 Nov 20;82(1):218. doi: 10.1186/s13690-024-01442-x. ABSTRACT BACKGROUND: High-need, high-cost (HNHC) patients are a major focus of international healthcare reform. However, research on …

A randomized clinical trial of intranasal dexmedetomidine versus inhaled nitrous oxide for procedural sedation and analgesia in children

Scand J Trauma Resusc Emerg Med. 2024 Nov 20;32(1):117. doi: 10.1186/s13049-024-01292-0. ABSTRACT BACKGROUND: Procedural sedation and analgesia is an important part of pediatric emergency care, …

Investigation of renal tubular function with newly diagnosed type 1 diabetes mellitus during diabetic ketoacidosis

Diabetol Metab Syndr. 2024 Nov 20;16(1):276. doi: 10.1186/s13098-024-01506-6. ABSTRACT BACKGROUND: Proximal renal tubular dysfunction occurs during diabetic ketoacidosis (DKA) in type 1 diabetes. However, only …

Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway

Respir Res. 2024 Nov 20;25(1):412. doi: 10.1186/s12931-024-03039-y. ABSTRACT BACKGROUND: Abnormal pulmonary vascular development poses significant clinical challenges for infants with bronchopulmonary dysplasia (BPD). Although numerous …

Serum metabolomic profiling of incident type 2 diabetes mellitus in the Multi-Ethnic Study of Atherosclerosis and Rotterdam Study

J Clin Endocrinol Metab. 2024 Nov 20:dgae812. doi: 10.1210/clinem/dgae812. Online ahead of print. ABSTRACT OBJECTIVE: This study aimed to investigate serum metabolomic biomarkers associated with …

Regulation of mitochondrial oxidative phosphorylation through tight control of cytochrome c oxidase in health and disease – Implications for ischemia/reperfusion injury, inflammatory diseases, diabetes, and cancer

Redox Biol. 2024 Nov 10;78:103426. doi: 10.1016/j.redox.2024.103426. Online ahead of print. ABSTRACT Mitochondria are essential to cellular function as they generate the majority of cellular …