paediatrics
paediatrics

Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors

Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2407745121. doi: 10.1073/pnas.2407745121. Epub 2024 Dec 30. ABSTRACT Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive …

Palmitoylation-dependent association with Annexin II directs hepatitis E virus ORF3 sorting into vesicles and quasi-enveloped virions

Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2418751122. doi: 10.1073/pnas.2418751122. Epub 2024 Dec 30. ABSTRACT Historically considered to be nonenveloped, hepatitis E virus …

A comprehensive multicenter analysis of clinical, molecular, and imaging characteristics and outcomes of H3 K27-altered diffuse midline glioma in adults

J Neurosurg. 2025 Jan 10:1-12. doi: 10.3171/2024.8.JNS241180. Online ahead of print. ABSTRACT OBJECTIVE: The objective was to comprehensively investigate the clinical, molecular, and imaging characteristics …

A Childhood Langerhans Cell Histiocytosis With a Novel BRAFN486_T491delinsK Mutation: Good Response to Conventional Chemotherapy

J Pediatr Hematol Oncol. 2025 Jan 13. doi: 10.1097/MPH.0000000000002996. Online ahead of print. ABSTRACT Langerhans cell histiocytosis (LCH) is characterized genetically by diverse gene mutations …

Using “pop-up” clinics and live-attenuated influenza vaccine to reduce barriers to flu vaccination among college students

J Am Coll Health. 2025 Jan 10:1-5. doi: 10.1080/07448481.2024.2439864. Online ahead of print. ABSTRACT Background: College students have cited inconvenience, ease of forgetting, and lack …

Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates

PLoS Negl Trop Dis. 2025 Jan 10;19(1):e0012809. doi: 10.1371/journal.pntd.0012809. Online ahead of print. ABSTRACT BACKGROUND: The antigen Na-GST-1, expressed by the hookworm Necator americanus, plays …