paediatrics
paediatrics

Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes

Nat Commun. 2025 Feb 2;16(1):1268. doi: 10.1038/s41467-025-56496-4. ABSTRACT H1N1 influenza viruses are responsible for both seasonal and pandemic influenza. The continual antigenic shift and drift …

Clinical and genetic characteristics in two cases of Birt-Hogg-Dubé syndrome associated with papillary renal cell carcinoma and rare Folliculin (FLCN) variants

Cancer Genet. 2025 Jan 31;292-293:65-68. doi: 10.1016/j.cancergen.2025.01.007. Online ahead of print. ABSTRACT Birt-Hogg-Dubé syndrome (BHDS) is characterized by autosomal dominant alterations in the Folliculin (FLCN) …

Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis

STAR Protoc. 2025 Jan 31;6(1):103593. doi: 10.1016/j.xpro.2024.103593. Online ahead of print. ABSTRACT Here, we present a protocol for the rapid functional screening of gene editing …

Etiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents

Endocrine. 2025 Feb 2. doi: 10.1007/s12020-025-04176-0. Online ahead of print. ABSTRACT PURPOSE: Hyperprolactinemia in children and adolescents can result from various etiologies, including pituitary masses. …

The Impact of High Burden Idiopathic Premature Ventricular Contractions in Pediatric versus Adult Populations. A Retrospective Cohort Study

Pediatr Cardiol. 2025 Feb 2. doi: 10.1007/s00246-025-03784-x. Online ahead of print. ABSTRACT Idiopathic premature ventricular contractions (PVCs) can occur in up to 40% of children …

“All doctors should be trained in that”: The co-production and mixed-methods evaluation of an educational toolkit to enable safe, high-quality genetic healthcare for people with intellectual disability

Genet Med. 2025 Jan 29:101371. doi: 10.1016/j.gim.2025.101371. Online ahead of print. ABSTRACT PURPOSE: People with intellectual disability inequitably access high-quality genetic healthcare. Yet, they are …