Cross-Species Extrapolation of Neonatal Fc Receptor (FcRn) Binding Affinity to Predict Monoclonal Antibody Pharmacokinetics in Humans Using Physiologically Based Pharmacokinetic Modeling (PBPK): Are We There Yet?
ACS Pharmacol Transl Sci. 2025 Aug 5;8(9):3207-3220. doi: 10.1021/acsptsci.5c00356. eCollection 2025 Sep 12. ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a useful tool during drug …