medicine
medicine

Inhibition of acid sphingomyelinase increases SMN levels and connects sphingolipid metabolism to Spinal Muscular Atrophy

Biomed Pharmacother. 2025 Sep 29;192:118610. doi: 10.1016/j.biopha.2025.118610. Online ahead of print. ABSTRACT Spinal Muscular Atrophy (SMA) is a moderately rare disease that causes progressive motor …

S100A11/ANXA2 axis mediates electrotransduction to promote electrically-induced contraction in engineered myocardial tissues

Biomaterials. 2025 Sep 18;327:123712. doi: 10.1016/j.biomaterials.2025.123712. Online ahead of print. ABSTRACT Ischemic heart disease (IHD) manifests impaired myocardial systolic/diastolic and electrophysiological functions due to disrupted …

Enhanced Fear Memory in Adult Male C57BL/6 Mice Following Low-Dose Isoflurane Exposure During Juvenile Development

Brain Behav. 2025 Oct;15(10):e70816. doi: 10.1002/brb3.70816. ABSTRACT OBJECTIVE: To elucidate the neural mechanisms through which neonatal exposure to low-dose anesthetic isoflurane (ISO) enhances adult fear …