medicine
medicine

Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics

Nat Cardiovasc Res. 2023 Dec;2(12):1246-1261. doi: 10.1038/s44161-023-00370-3. Epub 2023 Dec 7. ABSTRACT Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal genetic heart disease characterized by …

Indole-3 Carbinol and Diindolylmethane Mitigated β-Amyloid-Induced Neurotoxicity and Acetylcholinesterase Enzyme Activity: In Silico, In Vitro, and Network Pharmacology Study

Diseases. 2024 Aug 16;12(8):184. doi: 10.3390/diseases12080184. ABSTRACT Background: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme …

Investigation of METTL3 as an inhibitor of kanamycin-induced ototoxicity via stress granule formation

Front Pharmacol. 2024 Aug 13;15:1430162. doi: 10.3389/fphar.2024.1430162. eCollection 2024. ABSTRACT BACKGROUND: Methyltransferase-like 3 (METTL3), a component of the N6-methyladenosine (m6A) methyltransferase family, exhibits significant expression …

Dihydromyricetin improves growth performance, immunity, and intestinal functions in weaned pigs challenged by enterotoxigenic Escherichia coli

Front Vet Sci. 2024 Jul 26;11:1421871. doi: 10.3389/fvets.2024.1421871. eCollection 2024. ABSTRACT Enteric infection is a major cause of enteric disorder in neonatal pigs during the …