medicine
medicine

Pharmacokinetic assessment of elexacaftor/tezacaftor/ivacaftor and their metabolites in maternal blood, cord blood, the neonate, and breastmilk of a cystic fibrosis carrier mother/affected fetus dyad

J Cyst Fibros. 2025 Nov 27:S1569-1993(25)02528-7. doi: 10.1016/j.jcf.2025.11.013. Online ahead of print. ABSTRACT There are a paucity of data regarding the pharmacokinetics (PK) of elexacaftor …

Exploring effects of chronic d-cycloserine administration on expression of GluN2 subunits and tripartite synaptic transmission in thalamocortical pathway

Br J Pharmacol. 2025 Nov 28. doi: 10.1111/bph.70262. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: d-cycloserine, N-methyl-d-aspartate/glutamate (NMDA) receptor co-agonist (GluN2A/GluN2B partial and GluN2C …

From knowledge to action: protocol for a mixed-methods evaluation of First Nations-led knowledge mobilisation on prenatal opioid exposure

BMJ Open. 2025 Nov 28;15(11):e111306. doi: 10.1136/bmjopen-2025-111306. ABSTRACT INTRODUCTION: First Nations communities in Canada are disproportionately impacted by prenatal opioid exposure (POE) and neonatal abstinence …

Effects of the Mediterranean Dietary Pattern on Gestational Diabetes Mellitus and Its Association with Maternal-Fetal Outcomes: A Systematic Review of Clinical Trials

Z Geburtshilfe Neonatol. 2025 Nov 28. doi: 10.1055/a-2748-7385. Online ahead of print. ABSTRACT In recent years, the role of healthy dietary patterns-particularly the Mediterranean diet-has …

Cost analysis of probiotic/synbiotic supplementation in infants in rural Kenya: a study from the PROSYNK trial

BMJ Paediatr Open. 2025 Nov 27;9(1):e003635. doi: 10.1136/bmjpo-2025-003635. ABSTRACT BACKGROUND: Undernutrition significantly contributes to infant mortality and underlies approximately 45% of global deaths in children …