J Clin Endocrinol Metab. 2025 Nov 4:dgaf605. doi: 10.1210/clinem/dgaf605. Online ahead of print.
ABSTRACT
Many transgender and gender diverse (TGD) youth experience gender dysphoria which can exacerbate mental health risk. Gender-affirming medical interventions, such as pubertal suppression using gonadotropin-releasing hormone agonists (GnRHa) and gender-affirming hormone therapy (GAHT), primarily aim to alleviate gender dysphoria, with overall goals of optimizing wellbeing. Here we discuss prospective, longitudinal studies published in the last 5 years examining mental health outcomes of GnRHa and GAHT for TGD youth and young adults, contextualize these findings within the current socio-political climate, and elaborate on the need for robust and comprehensive gender-affirming care for TGD youth.
PMID:41186191 | DOI:10.1210/clinem/dgaf605
