J Pak Med Assoc. 2025 Oct;75(10):1575-1579. doi: 10.47391/JPMA.11604.
ABSTRACT
OBJECTIVE: To determine the frequency of micro-organisms and their antibiotic susceptibility in acute burn wounds.
METHODS: The retrospective, descriptive, cross-sectional study was conducted at the Department of Burn and Plastic Surgery, Allama Iqbal Teaching Hospital/Dera Ghazi Khan Medical College, Dera Ghazi Khan, Pakistan, and comprised data from January 2020 to December 2022 of patients of either gender aged 1-70 years with acute partial and full thickness burns. Those aged 1-14 years were designated as the paediatric group. Surface swab cultures were collected after 72 hours or upon signs of infection, and analysed using standard microbiological techniques. The prevalence of micro-organisms and antibiotic susceptibility was assessed using the disc diffusion method. Data was analysed using SPSS 22.
RESULTS: Of the 450 patients, 167(37.1%) were males and 179(39.8%) were females. The overall mean age was 23.95±11.83 years, and there were 104(23.1%) patients of paediatric age. Pseudomonas aeruginosa was the most common finding 157(34.9%), followed by klebsiella pneumonia 68(15%), methicillin-resistant staphylococcus aureus 68(15%), methicillin-sensitive staphylococcus aureus 45(10%), escherichia coli 23(5.1%), acinetobacter 13(2.9%) and proteus 5(1.1%). Among the pan-drug resistant strains, 67(14.9%) were pseudomonas and 22(4.9%) were klebsiella. Imipenem and linezolid were the most effective antibiotics overall.
CONCLUSION: The most frequently isolated bacteria in burn wounds were pseudomonas aeruginosa, klebsiella pneumonia and staphylococcus aureus. Linezolid and imipenem were found to be the most effective against these isolates.
PMID:41243907 | DOI:10.47391/JPMA.11604
