J Perinat Med. 2025 Oct 29. doi: 10.1515/jpm-2025-0361. Online ahead of print.
ABSTRACT
Placental histopathology is an invaluable yet underutilized resource in obstetric care. While it offers unique insights into the etiology of adverse pregnancy outcomes, its clinical integration is often limited by inconsistencies in placenta submission, reporting delays, lack of standardized interpretation, and limited interdisciplinary dialogue. Certain placental abnormalities provide immediate clinical insights, guiding acute management decisions, while others indicate an increased risk of recurrence in future pregnancies. Additionally, many lesions help contextualize antenatal findings or clarify postnatal complications, offering valuable diagnostic and prognostic information. The article reviews the spectrum of placental lesions, ranging from common findings to rare high-risk entities, and their implications for future pregnancy outcomes. It examines both the persistent challenges and emerging opportunities associated with placenta-oriented counseling in modern obstetric practice. It also explores strategies for translating placental findings into actionable care, emphasizing the importance of implementing structured, multidisciplinary review processes. Furthermore, it highlights how placental histologic findings must be interpreted within the broader clinical context, considering maternal history, laboratory investigations, microbiological cultures, genetic analyses, and neonatal outcomes, to ensure their diagnostic relevance and support informed patient-centered decision-making focused on the maternal-placental-fetal triad.
PMID:41150053 | DOI:10.1515/jpm-2025-0361
