Saudi Med J. 2025 Apr;46(4):418-424. doi: 10.15537/smj.2025.46.4.20241083.
ABSTRACT
OBJECTIVES: To evaluate the antibiotic resistance patterns in common uropathogens isolated from pediatric patients.
METHODS: This was a retrospective chart review on the uropathogens causing first-time, community-acquired, symptomatic urinary tract infection (UTI). The data for this study was collected from one tertiary care hospital and 4 primary care centers in Riyadh, Saudi Arabia, with data spanning from 2017-2022. Diagnosis of UTIs was in line with the guidelines of the American Academy of Pediatrics.
RESULTS: Isolates were gathered from 610 patients, 101 (16.6%) of whom were male and 509 (83.4%) were female. The 3 most common species isolated were Escherichia coli (E. coli; 50.5% in males and 82.7% in females), Klebsiella pneumoniae (K. pneumoniae; 28.7% males and 10.4% females), and then Proteus mirabilis (5.9% males and 2.9% in females). Escherichia coli was more prevalent in females than in males (p<0.001). Multidrugresistant E. coli was isolated more often from males than in females (39.2% versus 23.5%, p=0.014). A similar but non-significant trend was observed in multidrug-resistant K. pneumoniae (48.1% versus 30.8%, p=0.128), extended-spectrum beta-lactamase (ESBL) producing E. coli (13.7% versus 11.9%, p=0.701), and ESBL-producing K. pneumoniae (18.5% versus 7.7%, p=0.151).
CONCLUSION: Our study indicates that surveillance of uropathogen resistance should differentiate between isolates gathered from male and female patients. This study also indicates a possible increase in ESBL-producing E. coli isolates, and an increase in multidrug-resistant E. coli isolates.
PMID:40254313 | DOI:10.15537/smj.2025.46.4.20241083
