J Perinatol. 2024 Aug 5. doi: 10.1038/s41372-024-02088-x. Online ahead of print.
ABSTRACT
OBJECTIVE: To evaluate the association between enteral sodium supplementation on growth and hypertension (HTN) in preterm infants.
STUDY DESIGN: A retrospective cohort study of infants born between 22-32 weeks and weighing 450-1500 grams (N = 821). Enteral sodium supplementation amounts, systolic blood pressures (SBP), weight gain, and other infant and maternal risk factors for HTN were electronically extracted.
RESULTS: Infants receiving sodium supplementation were smaller and less mature. Sodium supplementation improved serum sodium levels, weight gain, and head circumference growth without causing hypernatremia. There was no correlation between urine and serum sodium or urine sodium and weight gain. Although infants receiving sodium had higher average SBP and rates of HTN, analysis demonstrated sodium supplementation did not increase odds of hypertension (ORADJ 1.02;0.64-1.64). Postnatal steroids were associated with HTN.
CONCLUSIONS: In preterm infants with poor weight gain, enteral sodium supplementation improved growth without increasing hypertension or hypernatremia.
PMID:39103473 | DOI:10.1038/s41372-024-02088-x
