J Clin Lab Anal. 2025 Sep 30:e70104. doi: 10.1002/jcla.70104. Online ahead of print.
ABSTRACT
OBJECTIVE: This study investigates the innovative application of nanomaterial-based micro-devices aimed at enhancing the diagnosis and management of acyclovir (ACV) for herpes virus infections, specifically those caused by HSV-1, HSV-2, CMV, and VZV.
BACKGROUND: Herpes viruses are associated with various clinical diseases, highlighting the urgent need for effective antiviral therapies. Acyclovir remains a primary treatment option; however, its potential for kidney toxicity and allergic reactions necessitates careful dosage monitoring, particularly in immunocompromised patients.
METHODS: Recent advancements in drug monitoring systems have been developed to optimize dosing regimens and reduce the risk of misuse. This study focuses on the integration of biological and electrochemical nanosensors utilizing nanomaterials, which have shown significant improvements in detection capabilities and diagnostic sensitivity for ACV.
RESULTS: We delineate the novel features and applications of these micro-devices, emphasizing their unique configurations and unprecedented limits of detection.
CONCLUSION: This research illustrates how these advanced technologies can enhance existing methodologies in herpes virus management, ultimately leading to improved treatment outcomes.
PMID:41025254 | DOI:10.1002/jcla.70104
