J Perinatol. 2025 Sep 17. doi: 10.1038/s41372-025-02429-4. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the association between lung ultrasound score (LUS) and left ventricular eccentricity index at end-systole (LVEI-s) and end-diastole (LVEI-d) in preterm infants with respiratory failure.
STUDY DESIGN: This prospective pilot study included 38 ultrasounds on 20 premature infants with Transient Tachypnea of the Newborn (TTN) and Respiratory Distress Syndrome (RDS) requiring non-invasive ventilation at birth. LUS, LVEI-s, and LVEI-d were obtained daily for 72 h. Linear regression analysis was performed to determine correlation.
RESULTS: LUS positively correlated with LVEI-s (r = 0.47, p = <0.01) and LVEI-d (r = 0.63, p = <0.01) during the 72-hour study period in the RDS group, but not the TTN group. Correlation increased over the first 24 h (LVEI-s: r = 0.69, p = <0.01; LVEI-d: r = 0.68, p = <0.01) in the RDS group.
CONCLUSION: As LUS increases, both LVEI-s and LVEI-d demonstrate measurable changes in infants with RDS. This association may enhance precision in diagnostic stratification and optimizing fluid management in neonatal lung disease.
PMID:40962825 | DOI:10.1038/s41372-025-02429-4
