Proc IEEE Int Symp Biomed Imaging. 2025 Apr;2025. doi: 10.1109/isbi60581.2025.10980924. Epub 2025 May 12.
ABSTRACT
This study examines how multi-scale intrinsic connectivity networks (ICNs) relate to cognitive and behavioral functions in adolescents, focusing on attention/vigilance, working memory, and behavioral regulation. Leveraging the NeuroMark 2.2 multi-scale ICN template obtained from over 100,000 subjects, we obtained multi-scale ICNs from baseline resting-state fMRI data from the ABCD Study. For this study, we are interested in “the fronto- thalamo-cerebellar (FTC) circuitry” and choose the subdomains of Neuromark 2.2 that cover it: Cerebellar (CB), Subcortical – Extended Thalamic (SC-ET), Higher Cognition – Insular Temporal (HC-IT), and Higher Cognition – Frontal (HC-FR), previously identified as relevant to cognitive and behavioral functions. Employing a multivariate approach combining principal component analysis (PCA) and canonical correlation analysis (CCA), we examined associations between these multi-scale ICNs and cognitive-behavioral outcomes. Our findings revealed significant associations, particularly for one of the estimated canonical components, linking multi-scale ICNs to cognitive and behavioral measures across both discovery and replication sets. This connectivity pattern may serve as a potential marker for attention, working memory, and behavioral regulation, offering new insights into a wide spectrum of neurodevelopmental disorders including Attention-Deficit/Hyperactivity Disorder (ADHD).
PMID:41928912 | PMC:PMC13042259 | DOI:10.1109/isbi60581.2025.10980924
