Int Med Case Rep J. 2026 Mar 30;19:583796. doi: 10.2147/IMCRJ.S583796. eCollection 2026.
ABSTRACT
INTRODUCTION: Lamellar Ichthyosis (LI) is a rare, severe autosomal recessive genodermatosis present at birth as a collodion membrane. Managing this condition in resource-limited settings like Somaliland presents significant challenges due to limited diagnostic capabilities and multidisciplinary care.
CASE PRESENTATION: A one-day-old, full-term male neonate was presented to the dermatology department with a history of generalized skin encasement since birth and incomplete eyelid closure. The patient was born to consanguineous parents, with a family history of similar skin disorders among relatives. Clinical examination revealed a classic collodion membrane with bilateral ectropion and eclabium. Systemic examination was otherwise unremarkable. A clinical diagnosis of Lamellar Ichthyosis was made based on the classic presentation. Management involved bland emollients, ophthalmology referral for ocular lubricants, and extensive parental counseling. The patient was lost to follow-up after discharge, highlighting a common barrier to care in this context.
CONCLUSION: This case underscores the diagnostic and management challenges of rare genodermatoses in resource-limited settings. It emphasizes the critical role of clinical diagnosis, basic supportive care, and the need for improved patient education and follow-up systems to ensure continuity of care.
PMID:41940243 | PMC:PMC13048060 | DOI:10.2147/IMCRJ.S583796
