Semin Pediatr Surg. 2025 Oct 28:151568. doi: 10.1016/j.sempedsurg.2025.151568. Online ahead of print.
ABSTRACT
BACKGROUND: The aim of the study was an assessment of whether the age of patients with WT could be measured as a risk factor and an analysis of the treatment of patients over 10 years old.
METHODS: The data of 942 patients treated because of Wilms tumour from 1997 to 2022 were assessed.
RESULTS: Patients were divided by age into two groups: group 1 (888 (94,27%) patients age 0-9 years old) and group 2 (54 (5,73%) patients age 10-18 years old). In group 1, there were more patients at higher stage than in group 2 (p<0,05). The histology of low risk in group 1 versus group 2 occurred in 13,4% vs 3,7% patients, of intermediate risk in 66,2% vs 66,7% patients and high risk in 19,9% vs 29,6% patients. Results of treatment were assessed only in group 2 which is a limitation of this study. Overall 62,96% patients survived in this group.
CONCLUSION: Wilms tumour in children 10-18 years old is diagnosed at a higher stage and with worse histology. Overall survival in this age group is lower than in younger children, which is in line with the current literature.
PMID:41176468 | DOI:10.1016/j.sempedsurg.2025.151568
