Acta Neurochir (Wien). 2025 Nov 8;167(1):291. doi: 10.1007/s00701-025-06693-3.
ABSTRACT
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a chronic disease affecting the central nervous system (CNS) because of persistent measles virus (MeV) infection. Among the various treatment available the intraventricular interferon alpha administration demonstrated greater effectiveness.
METHOD: In this article is described the step-by-step surgical technique of the positioning of an intraventricular catheter connected to a rechargeable subcutaneous pump. The main surgical steps and the pump settings are illustrated in a supplementary video.
CONCLUSION: This surgical management guarantees a continuous drug release improving the therapeutic effect in terms of clinical and neuroradiological outcome and reducing the toxicity profile.
PMID:41205057 | DOI:10.1007/s00701-025-06693-3
