Diabetes Care. 2025 Oct 1:dc251086. doi: 10.2337/dc25-1086. Online ahead of print.
ABSTRACT
OBJECTIVE: To examine whether glycemic level modifies the association between gestational weight gain (GWG) and pregnant outcomes in type 2 diabetes-complicated pregnancies.
RESEARCH DESIGN AND METHODS: This multicenter retrospective study stratified 1,642 pregnant women with diabetes by third-trimester glycemic control. Associations between excessive GWG (eGWG) and pregnant outcomes were analyzed by group.
RESULTS: Although birth weight and odds of macrosomia and cesarean delivery were higher for all women with eGWG relative to those with adequate GWG, the effect estimates for birth weight and macrosomia were significantly higher with suboptimal glycemic control compared with optimal control (birth weight increase: 361.04 vs. 126.07 g, respectively, P = 0.007; adjusted odds ratio for macrosomia: 4.26 vs. 2.73, P = 0.002; cesarean delivery: 1.86 vs. 1.52, P = 0.738).
CONCLUSIONS: Overly stringent weight control should be treated with caution if optimal glycemic control is not achieved.
PMID:41032701 | DOI:10.2337/dc25-1086
