J Perinatol. 2025 Mar 5. doi: 10.1038/s41372-025-02256-7. Online ahead of print.
ABSTRACT
OBJECTIVE: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.
STUDY DESIGN: Patients admitted to the NICU at Tokyo Metropolitan Children’s Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.
RESULTS: ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.
CONCLUSION: Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.
PMID:40038542 | DOI:10.1038/s41372-025-02256-7
