JACC Basic Transl Sci. 2025 Apr 2:101229. doi: 10.1016/j.jacbts.2025.01.010. Online ahead of print.
ABSTRACT
A modified neonatal rat model of pulmonary vein stenosis (PVS) via bilateral pulmonary vein banding was introduced for the first time, providing a platform for understanding the pathophysiology of PVS and developing treatments. In addition, using this model, the mTOR inhibitor sirolimus was evaluated as a treatment for PVS and exhibited significant therapeutic effects, indicating the need for accelerated ethics approval in clinical settings where sirolimus is not yet in use.
PMID:40464728 | DOI:10.1016/j.jacbts.2025.01.010
