BMJ Public Health. 2025 Oct 13;3(2):e002733. doi: 10.1136/bmjph-2025-002733. eCollection 2025.
ABSTRACT
BACKGROUND: There has been little decline in neonatal mortality rates over recent decades, and this is now further challenged by the rising prevalence of antimicrobial resistance. In Australia, the incidence of neonatal sepsis is low on a global scale, yet there are increasingly frequent outbreaks of multidrug-resistant (MDR) infections in neonatal intensive care units, alongside rising rates of colonisation with MDR bacteria.
METHODS: We analysed positive blood and cerebrospinal fluid cultures collected from infants (aged 0 to ≤180 days) across five clinical sites in Australia between 2010 and 2019, to determine evolving antimicrobial susceptibility profiles.
RESULTS: After excluding presumed contaminants, we analysed 743 pathogenic bacterial isolates cultured from 624 neonates and infants with early-onset (≤72 hours), late-onset (>72 hours to ≤28 days) and very late-onset (>28 days to ≤180 days) infections. Escherichia coli (37%) and Streptococcus agalactiae (31%) were the primary pathogens responsible for early-onset bloodstream infections, while coagulase-negative staphylococci, E. coli and Staphylococcus aureus were responsible for most infections in older neonates and infants. Antimicrobial susceptibility to currently recommended empiric regimens remains high; however, gram-negative bacteria-including MDR bacteria-were responsible for an increasing proportion of very late-onset infections over the study period (22% in 2010-2014 vs 34% in 2015-2019; p=0.07).
CONCLUSIONS: Although empiric antimicrobial regimens remain adequate for most pathogens causing infections in neonates and infants in Australia, there is an increasing burden of invasive infections caused by gram-negative bacteria. Ongoing surveillance is necessary to ensure empiric antimicrobial guidelines remain efficacious and appropriate.
PMID:41099041 | PMC:PMC12519648 | DOI:10.1136/bmjph-2025-002733
