Respir Physiol Neurobiol. 2024 Sep 5:104338. doi: 10.1016/j.resp.2024.104338. Online ahead of print.
ABSTRACT
OBJECTIVE: To determine if change in body position improves oxygen requirements and respiratory mechanics during the transition from total liquid ventilation (TLV) to gas ventilation.
METHODS: Fourteen piglets underwent TLV, followed by a 2-hour weaning period under conventional gas ventilation. Subjects were randomized to the experimental group (Rotating – R), that was in prone position between the 10th and 30th minute of weaning, or to the static control group (Supine – S).
RESULTS: Oxygenation index was lower in the R group at 30minutes in prone position than that in the S group (1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001). This difference disappeared when subjects resumed the supine position (4.2 [3.8; 4.7] and 4.7 [3.8; 5.4], p = 0.4, for the R and S groups, respectively). The change in body position did not affect respiratory system compliance or inspiratory capacity.
CONCLUSION: Prone position improved oxygenation during weaning from TLV. The effect disappeared once piglets returned to the supine position.
PMID:39244183 | DOI:10.1016/j.resp.2024.104338
