Eculizumab treatment of tacrolimus-associated autoimmune haemolytic anaemia and thrombotic microangiopathy in a child with orthotopic heart transplant
Eculizumab treatment of tacrolimus-associated autoimmune haemolytic anaemia and thrombotic microangiopathy in a child with orthotopic heart transplant

Eculizumab treatment of tacrolimus-associated autoimmune haemolytic anaemia and thrombotic microangiopathy in a child with orthotopic heart transplant

Cardiol Young. 2025 Aug 1:1-3. doi: 10.1017/S1047951125101339. Online ahead of print.

ABSTRACT

BACKGROUND: Tacrolimus is the standard immunosuppressant used in paediatric orthotopic heart transplantation, but it can be associated with rare and life-threatening haemolysis.

METHODS: Retrospective chart review was used for this case report.

RESULTS/CONCLUSION: We present the case of a 6-year-old heart transplant recipient who developed life-threatening haemolysis in the setting of mycoplasma infection while on tacrolimus immunosuppression that was treated successfully with eculizumab.

PMID:40747633 | DOI:10.1017/S1047951125101339