Clin Exp Dermatol. 2024 Oct 11:llae418. doi: 10.1093/ced/llae418. Online ahead of print.
ABSTRACT
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) is a severe adverse drug reaction with significant variation between patients concerning presenting symptoms and disease severity. Under the hypothesis that the clinical presentation of DReSS is drug-specific, we performed a scoping review and identified 644 cases of pediatric DReSS. A single implicated drug was present in 262 cases, and drugs with 10 or more cases were included in this analysis (n=224): carbamazepine (n=86), dapsone (n=16), lamotrigine (n=25), phenobarbital (n=38), phenytoin (n=45), and trimethoprim-sulfamethoxazole (n=14). Dapsone was associated with increased organ involvement, the highest mortality rate, and the longest period of hospitalization. In addition, we showed that trimethoprim-sulfamethoxazole was associated with higher rates of auto-immune sequelae. This study confirms that drug-specific features exist and may impact the acute and long-term management of DReSS in children.
PMID:39392933 | DOI:10.1093/ced/llae418
