Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study
Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study

Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study

J Pediatr. 2024 Sep 19:114322. doi: 10.1016/j.jpeds.2024.114322. Online ahead of print.

ABSTRACT

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving post-operative extracorporeal membrane oxygenation (ECMO) support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor ECMO outcomes.

PMID:39306320 | DOI:10.1016/j.jpeds.2024.114322