Diabetes Care. 2025 Jun 6:dc250283. doi: 10.2337/dc25-0283. Online ahead of print.
ABSTRACT
OBJECTIVE: To assess the association between daily carbohydrate (CHO) entries and glycemic outcomes in youth with type 1 diabetes after automated insulin delivery (AID) initiation in real-life settings.
RESEARCH DESIGN AND METHODS: In this longitudinal, multinational observational study, 347 young individuals (7-21 years old) with type 1 diabetes for >1 year were followed for >6 months after AID initiation. Clinical data, including daily and overall continuous glucose monitoring-based time in range (TIR) (70-180 mg/dL), time in tight range (TITR) (70-140 mg/dL), and CHO entry metrics, were evaluated.
RESULTS: Day-to-day variability in CHO entries was negatively associated with overall TIR (P < 0.001) and TITR (P < 0.001). Higher deviation in daily CHO entry was associated with lower daily TITR and TIR (both P < 0.001). Overall TIR and TITR after AID initiation were 75.0% and 50.3%, respectively.
CONCLUSIONS: Variability in CHO entries is associated with lower TIR, emphasizing the importance of consistent premeal bolus routine when using AID.
PMID:40478457 | DOI:10.2337/dc25-0283
