Indian Pediatr. 2025 Apr 15. doi: 10.1007/s13312-025-00037-1. Online ahead of print.
ABSTRACT
BACKGROUND: IntercellularAQ1 adhesion molecules (ICAMs) are released from the endothelium in response to shear stress. Their role in persistent pulmonary hypertension (PPHN) remains un-investigated.
METHODOLOGY: Sixty neonates (30 PPHN, 30 controls) underwent serum ICAM testing and echocardiography.
RESULTS: Right and left ventricular function was depressed in PPHN cases. Tricuspid annular plane systolic excursion was reduced (Cases 8±1 vs. Controls 11±3.5). ICAM was elevated in cases (332±96 vs. 208 ±36).
CONCLUSION: ICAM is a sensitive PPHN marker. Elevated ICAM may result from endothelial damage or contribute to PPHN pathogenesis. Further studies are needed to confirm these results and explore this relationship.
PMID:40232560 | DOI:10.1007/s13312-025-00037-1
