Paediatrics
Paediatrics

High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases

Protein Sci. 2025 Apr;34(4):e70088. doi: 10.1002/pro.70088. ABSTRACT While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease …

Impact of continuous renal replacement therapy and Cytosorb on cefiderocol pharmacokinetics: “One size does not fit all”

Int J Artif Organs. 2025 Mar 18:3913988251322702. doi: 10.1177/03913988251322702. Online ahead of print. ABSTRACT Cefiderocol, a novel broad-spectrum cephalosporin, exhibits promising efficacy against carbapenem-resistant Gram-negative …

Cochlear implant procedure. Italian Clinical Practice Guidelines of the Italian Society of Otorhinolaryngology (SIOeChCF) and Italian Society of Audiology and Phoniatrics (SIAF). Part 1: cochlear implants in adults

Acta Otorhinolaryngol Ital. 2025 Feb;45(1):47-57. doi: 10.14639/0392-100X-N3081. ABSTRACT OBJECTIVE: Cochlear implant (CI) is a well-established treatment for adults with sensorineural hearing loss and without benefit …