Paediatrics
Paediatrics

Explainable Artificial Intelligence (XAI) in the Era of Large Language Models: Applying an XAI Framework in Pediatric Ophthalmology Diagnosis using the Gemini Model

AMIA Jt Summits Transl Sci Proc. 2025 Jun 10;2025:566-575. eCollection 2025. ABSTRACT Amblyopia is a neurodevelopmental disorder affecting children’s visual acuity, requiring early diagnosis for …

Identifying Space-Resolved Proteins of the Murine Thymus, by Combining MALDI Mass Spectrometry Imaging and Proteomics

bioRxiv [Preprint]. 2025 Jun 5:2025.06.02.657511. doi: 10.1101/2025.06.02.657511. ABSTRACT The identification of spatially resolved proteomes has recently seen significant breakthroughs, yet challenges persist, particularly in integrating …

Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques

bioRxiv [Preprint]. 2025 May 30:2025.05.27.656273. doi: 10.1101/2025.05.27.656273. ABSTRACT A vaccine capable of inducing broadly neutralizing antibodies (bnAbs) is essential for effective prevention against HIV in …

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation

bioRxiv [Preprint]. 2025 May 29:2025.05.28.656712. doi: 10.1101/2025.05.28.656712. ABSTRACT Hematopoietic stem and progenitor cells (HSPC) respond to infections, inflammation, and regenerative challenges using a collection of …

Efficacy of Short-Course High-Dose Oral Prednisolone in Rapid Platelet Recovery for Pediatric Acute Immune Thrombocytopenic Purpura: A Prospective Cohort Study

J Hematol. 2025 Jun;14(3):133-138. doi: 10.14740/jh2052. Epub 2025 May 13. ABSTRACT BACKGROUND: Standard management of acute immune thrombocytopenic purpura (ITP) remains debated, with some advocating …

2′-Fucosyllactose Modulates the Intestinal Immune Response to Gut Microbiota and Buffers Experimental Colitis in Mice: An Integrating Investigation of Colonic Proteomics and Gut Microbiota Analysis

Food Sci Nutr. 2025 Jun 10;13(6):e70418. doi: 10.1002/fsn3.70418. eCollection 2025 Jun. ABSTRACT Inflammatory bowel disease (IBD), a recurrent gastrointestinal disease, is characterized by dysbiosis and …