Paediatrics
Paediatrics

DNA methylation and hydroxymethylation combined with transcriptional profiling identify key regulators of hyperoxia-induced bronchopulmonary dysplasia

Clin Epigenetics. 2025 Jul 4;17(1):116. doi: 10.1186/s13148-025-01926-9. ABSTRACT BACKGROUND: Hyperoxia-induced bronchopulmonary dysplasia (BPD) is a major cause of lung injury in premature infants. Epigenetics, particularly …

Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer’s disease in cerebrospinal fluid

Alzheimers Res Ther. 2025 Jul 4;17(1):147. doi: 10.1186/s13195-025-01789-5. ABSTRACT BACKGROUND: The complex pathogenesis of Alzheimer’s disease (AD) has resulted in limited current biomarkers for its …

Intraoperative Contrast-Enhanced Ultrasonography in Pediatric Surgeries: A Review of Techniques, Applications, and Outcomes

J Clin Ultrasound. 2025 Jul 4. doi: 10.1002/jcu.24096. Online ahead of print. ABSTRACT Contrast-enhanced ultrasound (CEUS) utilizes microbubble contrast agents to improve imaging clarity during …

Combined surgery with intramedullary rod fixation across the ankle for the treatment of Crawford IV congenital pseudarthrosis of the tibia: a long-term follow-up study

Orphanet J Rare Dis. 2025 Jul 4;20(1):343. doi: 10.1186/s13023-025-03873-3. ABSTRACT BACKGROUND: The combined surgery with tibial intramedullary (IM) rod fixation across the ankle for the …

Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis

J Nanobiotechnology. 2025 Jul 5;23(1):486. doi: 10.1186/s12951-025-03543-3. ABSTRACT BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack …

Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study

Respir Res. 2025 Jul 4;26(1):236. doi: 10.1186/s12931-025-03312-8. ABSTRACT BACKGROUND: Pulmonary emphysema occurs frequently in older adults, often without airflow limitation. Its presence predicts symptoms, respiratory …