Paediatrics
Paediatrics

The clinical analysis and indications for exchange transfusion in 158 children with pertussis characterized by marked leukocytosis

Ital J Pediatr. 2025 Jul 15;51(1):224. doi: 10.1186/s13052-025-02077-6. ABSTRACT BACKGROUND: Hyperleukocytosis (WBC ≥ 30 × 10⁹/L) strongly associated with fatal outcomes; evidence-based thresholds for initiating …

DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus

Microbiome. 2025 Jul 14;13(1):164. doi: 10.1186/s40168-025-02151-5. ABSTRACT BACKGROUND: Oral lichen planus (OLP) is one of the most frequent oral mucosal diseases associated with chronic inflammation, …

Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation

Epigenetics Chromatin. 2025 Jul 14;18(1):44. doi: 10.1186/s13072-025-00610-9. ABSTRACT BACKGROUND: MED12 is a key regulator of transcription and chromatin architecture, essential for normal hematopoiesis. While its …

Left ventricular myocardial functions in pediatric patients with primary nephrotic syndrome: a comprehensive evaluation using conventional echocardiography, two-dimensional speckle tracking, and three-dimensional echocardiography

Ital J Pediatr. 2025 Jul 15;51(1):234. doi: 10.1186/s13052-025-02086-5. ABSTRACT BACKGROUND: Nephrotic syndrome (NS) has been linked to cardiac morbidity and mortality. However, early cardiac implications …

Development of an early mortality risk prediction model for pediatric patients with secondary hemophagocytic lymphohistiocytosis

Ital J Pediatr. 2025 Jul 14;51(1):221. doi: 10.1186/s13052-025-02084-7. ABSTRACT BACKGROUND: To establish a visual prediction model for the risk of early mortality in pediatric patients …