Paediatrics
Paediatrics

Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways

J Nanobiotechnology. 2025 Aug 21;23(1):579. doi: 10.1186/s12951-025-03639-w. ABSTRACT Developmental neurotoxicity (DNT) induced by sevoflurane exposure poses significant risks to pediatric anesthesia, yet effective protective strategies …

Identity development and adaptation in adolescents with genetic conditions: a qualitatively oriented mixed-methods study to develop strategies for optimizing clinical genetics services

Orphanet J Rare Dis. 2025 Aug 21;20(1):450. doi: 10.1186/s13023-025-03968-x. ABSTRACT BACKGROUND: Genetic counselling for adolescents necessitates an approach distinct from that used with adults. Developing …

Biomimetic epiphysis inspired by natural developmental mechanisms promote the repair of large-scale epiphyseal defects

Biomaterials. 2025 Aug 19;326:123644. doi: 10.1016/j.biomaterials.2025.123644. Online ahead of print. ABSTRACT Epiphysis is an organized and dynamically evolving developmental tissue that is susceptible to physical …